Joe DiCarlo 
We are moving right along through the NFL season as we are past the midway point and grinding our way week-to-week in DFS. This slate gets cut down to 10 games thanks to a few teams on bye, but we’ll still have plenty to work with. Let’s not waste any more time and cut right to the Breakdown, the injuries are piling up for the season and we have a lot to chop it up about!
Stay tuned for all our injury news, updates, and Discord-building advice. Also, check out our Optimizer and Projection Models to get the best possible performance from your lineups. Also, check back into the article during the week as we approach kickoff for more content, as more game breakdowns will be available as we approach the Sunday Slate.
Sunday Main Slate 11/10/24
Bills @ Colts (+4) (O/U 46)
Buffalo will keep the pedal to the metal as they land in Indianapolis to battle the Colts in our kickoff of Week 10. Joe Flacco looked like Joe Flacid last weekend and will need to step up his game against the top dog in the AFC East if he wants to keep Indianapolis in the playoff race. The 46 total is decent, so we should have no worries about taking a slice of this game on the slate for lineups.
Besides Josh Allen who is a lock for cash games week in and week out, what other Bills can be viable this weekend against a Colts’ defense that ranks in the bottom ten of the league against the run and the pass. Keep an eye out for Amari Cooper’s wrist injury, if he sits out again we may want to double down with Khalil Shakir, Keon Coleman, and or Dalton Kincaid. James Cook will see a run defense that allows 150 yards per game and could be worth every penny of his $7K salary on DraftKings.
Indy will run it back with Flacco again and hope he will be able to get the ball into the hands of his playmakers. Second-year wideout Josh Downs has become the clear-cut target share leader in the receiver room with a 27% target share for the season with nine last weekend from Flacco. But the running game will need to be established first, so expect to see plenty of Jonathan Taylor against the Bills’ 31st in DVOA to opposing running backs.
Cash: Josh Allen, Jonathan Taylor
GPP: James Cook, Khalil Shakir, Josh Downs
Update: Michael Pittman and Keon Coleman are out.
Steelers @ Commanders (-2.5) (O/U 45.5)
The schedule is beginning to get tougher for the league’s arguable QB1 going into this weekend Jayden Daniels as the Steelers visit the Commanders. Vegas is not intimidated by the Steelers’ defense giving them a 45.5-point total, so we may see some back-and-forth potential between Wilson and Daniels. Let’s see how this may play out.
The secondary has been beefed up in Washington this past week as the Commanders traded for Marshon Lattimore with the Saints. They’ve only been allowing 184 yards through the air before the trade, so expect Wilson to not be as effective down the field. Pittsburgh may lean more on their running game, where Washington has struggled, allowing over 140 yards per game. Najee Harris and Jaylen Warren will offer some GPP appeal in the $6K range at running back the week for DFS.
Washington is rolling with the rookie Daniels under center, winning five of their last six games and having the third-best overall offense in the league. If Daniels can stay elusive from the Steelers’ pressure, then Terry McLaurin may have enough time to shake Joey Porter to get open, who currently ranks 77th in coverage with a +14.6 rating. Also, watch the status of running back Brian Robinson who is still nursing a hamstring. If he sits out again it will be more reps for Austin Ekeler out of that explosive backfield, and priced under $6K on DraftKings.
Cash: Jayden Daniels, Najee Harris
GPP: Russell Wilson, Terry McLaurin, George Pickens, Austin Ekeler
Update: Brian Robinson is OUT
Falcons @ Saints (+3.5) (O/U 46)
Here we have an NFC South matchup as Atlanta travels to The Big Easy to take on the Saints. New Orleans fired their head coach Dennis Allen this week, so we may see some changes to the scheme in the upcoming weeks. Seems like they are preparing for a rebuild as they also traded All-Pro cornerback Marshon Lattimore this week to the Commanders for a third and fourth-round pick.
Atlanta should have a walk in the park this week on offense, as the Saints were 26th overall on defense before the Lattimore trade and Allen firing. Even Carolina locked up a win against this roster, so this game should be cake for Cousins and the crew. Just keep an eye on Drake London during the week as he suffered a hip pointer in the first quarter of last week’s game. The Falcons’ DST is also a solid option this week for DFS.
As for the Saints, it’s still the Alvin Kamara show, who has shown us to be extremely durable this season. He is currently ranked number one among running backs in targets and receptions, and averaging 21 fantasy points per game this season. He may see plenty of stacked boxes when on the field, so keep him in tournaments at his very high salary. Perhaps let’s go back to the Taysom Hill well that I suggested in last week’s Breakdown due to the lack of pass-catchers and running backs. He put up 16 fantasy points, catching five balls for 51 yards and a score while adding 41 yards rushing. Still underpriced at $4K on DraftKings.
Cash: Bijan Robinson, Kirk Cousins
GPP: Alvin Kamara, Taysom Hill, Kyle Pitts, Drake London (if healthy) Darnell Mooney, Saints DST
Vikings @ Jaguars (+4) (O/U 47)
The Vikings are back on track and will look to keep their momentum out in Jacksonville on Sunday against the 2-7 Jaguars. It’s only a four-point spread but it’s a game that can easily get out of hand considering how bad the Jags have been defensively. A great game to pick pieces from for lineups because of each team’s desire to put the ball in the air against their terrible secondaries…Enjoy!
Jacksonville is nearly dead-last in points allowed, passing with total yards allowed per game, it’s gross. Play plenty of purple jerseys this weekend in your lineups, especially Jefferson who is always good for 20-plus fantasy points. Aaron Jones has calmed down recently, putting up a few duds in the last couple of weeks. This week may be his get-right spot as we all witnessed Saquon go bananas at home against that run defense, and he’s used heavily in the fourth quarter to eat up the clock.
The Jags’ season is pretty much dead in the water, and playing for pride the rest of the way. Minnesota does offer the worst overall DVOA in the passing game, so if Trevor Lawrence can shake the left shoulder soreness he could quadruple his value again like he did in Phila. His best receiver Brian Thomas is pricey ($6,600 on DK), but would be a target funnel along with tight end Evan Engram and Parker Washington. Stay clear of the Jags’ backs this week since Minnesota has been tough in the trenches (82 YPG allowed)
Cash: Justin Jefferson
GPP: Sam Darnold, Trevor Lawrence, Jordan Addison, Aaron Jones, Evan Engram, Parker Washington, MIN DST
Update: Trevor Lawrence is unlikely to play, and Mac Jones is to start.
Patriots @ Bears (-6) (O/U 39)
The Patriots narrowly lost by a field goal in Tennessee and will be in over their heads on Sunday at Soldier Field against the Bears’ fifth-ranked defense. The Bears sit in a perfect bounce-back spot after dropping two straight games and will aim to make mincemeat of the Pats at home. It’s a low total with a wide spread so let’s see where to attack here for DFS.
The Patriots have been a punching bag to their opponents all year, allowing the football to move up and down the field no matter who they are facing. This will turn out to be a game for Caleb Williams and the Bears to let out some frustration, especially after last week’s 29-9 loss to the Cardinals. Pick your poison of Chicago’s skill players for GPPs this weekend. Their defense is also in play.
If I were to risk my hard-earned cash on anybody for the Patriots, it would be on Rhamondre Stevenson. The Bears allow over 130 rushing yards per game and Stevenson has been their multi-faceted back that has scored four times in his last two games. He is a discount on his DraftKings salary ($6,400), as the only game in town for New England take your shot in GPPs. If you feel the Bears will also struggle offensively this week, the Jerod Mayo Pats’ defense is another bargain on DK for $2,500.
Cash: None
GPP: Caleb Williams, D’Andre Swift, DJ Moore, Keenan Allen, Cole Kmet, Bears DST, Rhamondre Stevenson, Patriots DST
Broncos @ Chiefs (-8) (O/U 41.5)
We get the world champs this week back on the slate as they’ll host their division rival Denver Broncos. Kansas City will look to stay undefeated in front of a home crowd while the Broncos look to stay above .500 on the road. Pat Mahomes is coming off his best performance of the season and should be able to replicate it this week as an eight-point favorite.
The Broncos have been solid all season on defense, ranking third on the season in overall points allowed, but not as of late. Baltimore gashed them for 41 last weekend, as Lamar Jackson threw for three scores- two to Zay Flowers. Unless this was a hiccup from this Vance Joseph defense we could see another bludgeoning by the Chiefs. Mahomes is always a lock and his weapons of Kelce and DeAndre Hopkins are also viable. Kareem Hunt averaging over 20 carries per game has proven to be a true workhorse again for this offense. But he may be a bit pricey salary-wise for DFS this week.
Head Coach Sean Payton has truly been gifted at developing quarterbacks over his career, as rookie Bo Nix has been a top 12 quarterback on the season so far. He’ll see a true test of skill against a top defense in Kansas City where DC Steve Spagnuolo has suffocated his opponents. I am not investing in any Broncos this week, as the Chiefs currently rank first against running backs and hold their opposition to 18 points per game.
Cash: Pat Mahomes, Travis Kelce
GPP: DeAndre Hopkins, Chiefs DST
Niners @ Bucs (+5) (O/U 51)
The Niners are fresh and healthier off a Week 9 bye and will travel to Tampa to face off against the Bucs. It looks to be pretty high-scoring as the only game on the slate with a total over 50. Tampa came close to defeating the Super Bowl champs on Monday night, but fell short on a coin toss in overtime and allowing them to score a TD. They’re five-point dogs at home, but I believe it will be a much closer game because of Baker Mayfield’s competitiveness.
The Bucs defensively have been a dumpster fire, averaging well over 30 points per game in their last three contests. Mainly giving up chunks of yardage and end zone targets through the air, look for Brock Purdy to continue to expose their holes on defense. Deebo Samuel, George Kittle, and Jauan Jennings will all feast from Tampa’s 30th-ranked pass defense. Cristian McCaffrey is set to make his debut this week, but I do not expect a full workload if he does in fact play. He is still priced up for DFS so best to keep him out of your lineups until we get a full sample.
Baker will do his best to keep up with the Niners’ pace so expect him to do what he has been doing…chuck the pigskin. He’s logged well over 120 attempts in his last three games, but his problem is the talent level at receiver has been depleted due to injuries. Tight end Cade Otton has been his go-to guy since Godwin and Evans went down in Week 7, racking up 25 catches on 31 targets for 256 yards and three scores. He’ll be a cash game play but his fellow receiver teammates who all lurk in the low $4K range on DraftKings should be used in GPPs.
Cash: Cade Otton, Brock Purdy
GPP: Baker Mayfield, Deebo Samuel, George Kittle, Sterling Shepard, Jauan Jennings, Jalen McMillan, Rachaad White
Titans @ Chargers (-7.5) (O/U 38)
The Titans, who finally get a win to go a miserable 2-7 against the Patriots last week, travel to LA to face a Chargers’ defense that has put their opponents in a vice offensively (ranked first in points allowed). LA has won two of their last three and look comfortable sitting at 5-3 going into this matchup as a touchdown favorite. Not too much to decide on here for DFS as both clubs are pretty cut and dry to dissect.
The low total and wide point spread tell us to start up that Chargers’ defense, obviously, but who else is worth a shot for LA? Well, Justin Herbert seems to be throwing the football more often these days, and pretty efficiently. He’s passed for 280 yards and two touchdowns in his last two games. Not lighting up the scoreboard but for only $5,200 on DraftKings, that’s four times his value. Pair him up with Quentin Johnston or Ladd McKonkey for even more bang for your buck, or just stay safe with JK Dobbins at running back who’s been a bell cow all season. All are solid GPP options.
Tennessee will continue to focus on their run game as they play hide the quarterback with Mason Rudolph and Will Levis. Tony Pollard has carried a questionable tag for two weeks straight, yet he still will see twenty-plus carries when he is on the field. The Titans will get every dollar out of Pollard this year, but for DFS he may be priced out at $6,900 on DraftKings. Consider Calvin Ridley at only $5,700 as another option as he is the last man standing seeing close to 20 targets since the departure of DeAndre Hopkins to KC. GPP only fellas.
Cash: Chargers DST
GPP: JK Dobbins, Justin Herbert, Ladd McKonkey, Quentin Johnston, Calvin Ridley
Eagles @ Cowboys (+7) (O/U 42)
The white-hot Eagles will visit the Dak-less Cowboys at AT&T Stadium in what looks to be a beatdown in front of a home crowd in Dallas. Philadelphia will look to make a statement to their division rival Cowboys and keep in the race against Washington for first place. Hopefully, this game is not over by halftime and Dallas will keep the Eagles honest.
Philadelphia will do what they do best offensively, enforce the running game by utilizing one of the best O-lines in football. Dallas already ranks 30th defending against it, so basically prepare to see another blood bath in the boxscore between Saquon Barkley and Jalen Hurts. Their pass catchers are always in play, but keep an eye on Devonta Smith as he’s been missing practice this week due to a hamstring. Tight end Dallas Goedert is set to return after missing four weeks and should see some work especially if Devonta is out.
Cooper Rush will look to pick up where he left off in Atlanta filling in for Dak Prescott, as he threw for 115 yards and a touchdown. But Phila’s DC Vic Fangio may have his number this weekend as Rush has no quality running game behind him and will focus entirely on smothering CeeDee Lamb. Startup that Eagles DST, it could get ugly. However, Rush will have to get the ball out elsewhere if Lamb doesn’t get open, and perhaps tight end Jake Ferguson. Keep Dem’ Boyz in tournaments only.
Cash: Jalen Hurts, Saquon Barkley, Eagles DST
GPP: Cee Dee Lamb, Jake Ferguson, AJ Brown, Dallas Goedert, Devonta Smith (if healthy)
Jets @ Cardinals (-1) (U/O 46)
New York is on the brink of making the playoffs and desperately need a win to stay alive, They’ll be the on the road to face the Cardinals, who currently have first place in their division. There’ll be loads of talent in State Farm Stadium to wrap up the Main Slate this week, so with a lot at stake we can expect both clubs to come out swinging.
It’s win or start looking for a new job for Gang Green, so expect the Jets to be ramped up for battle. Arizona sits in the bottom tier defensively, ranking 22nd on the ground and 24th through the air. New York’s offense is pretty condensed, we’ll see Rodgers utilize Breece Hall out of the backfield and Wilson and Adams to get the majority of the targets. All useful in cash or GPP lineups.
As well as the Cardinals have been record-wise, for fantasy it’s been a roller coaster. Inconsistency has been all over Kyler Murray along with Trey McBride and Marvin Harrison, yet running back James Conner just keeps padding up his stats. Only two of nine weeks he has scored less than ten fantasy points, and against a Jets’ run defense that gets hammered every week for 130-plus yards per game, run him back.
Cash: Breece Hall, Garrett Wilson, James Conner
GPP: Kyler Murray, Aaron Rodgers, Davante Adams, Trey McBride, Marvin Harrison
Thanks for reading my NFL DFS Game by Game Breakdown for Week 10! Remember to check back daily for more updates and content up until kickoff. You can reach me on X @JoeDiCarlo78 or in our Discord tag me @DiCarlo78 for any lineup build opinions or questions, always here to help! Gain access to our Projection Models and jump into our Discord where we will have our experts and myself talking plays across every sport 24/7/365!
